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KMID : 0811720020060030161
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Korean Journal of Physiology & Pharmacology
2002 Volume.6 No. 3 p.161 ~ p.163
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Assessment of an Apo-1/Fas Promoter Polymorphism in Korean Schizophrenia Patients
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Joo Ho Chung/Soon Ae Kim
Youn Jung Kim/Bong Keun Choe/Hee Jae Lee/Jong Woo Kim/Jong Deuk Park†/Chang Ju Kim/Seung Joon Park/Jee Chang Jung/Joo Ho Chung
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Abstract
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Apoptosis has been hypothesized to be involved in the pathogenesis in schizophrenia. A large number of genes are known to mediate the apoptotic process; Apo-1/Fas (CD95) is a well-known example of such genes. In the present study, MvaI restriction fragment length polymorphism, a polymorphic marker present within the Apo-1/Fas gene, was examined in a population consisting of 226 control subjects and 110 schizophrenia patients, all of them Korean in ethnicity. No statistically significant difference in the genotypic distribution and allelic frequencies was observed between the control and the schizophrenia patient group. To find out the precise effect of Apo-1/Fas gene polymorphisms on the susceptibility to schizophrenia, further studies are warranted to investigate possible involvement of other polymorphisms with a larger sample population.
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KEYWORD
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Schizophrenia, Apoptosis, CD95, Promoter regions, Restriction fragment length polymorphism,
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